Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA
Madeline L. Page, Elizabeth L. Vance, Mark TW Ebbert, CD Smith, GA Jicha, RE Khouli, FD Raslau, and Justin B. Miller
Department of Biology, Brigham Young University, Provo, UT, USA
Matthew E. Cloward, Ed Ringger, Louisa Dayton, and John SK Kauwe
Division of Biomedical Informatics, Department of Internal Medicine, University of Kentucky, Lexington, KY, USA
Mark TW Ebbert and Justin B. Miller
Department of Neuroscience, University of Kentucky, Lexington, KY, USA
Mark TW Ebbert
Department of Pathology and Laboratory Medicine, University of Kentucky, Lexington, KY, USA
Justin B.Miller
University of California, San Francisco, San Francisco, California, USA
MW Weiner, J. Fockler, J. Neuhaus, C. Jin, R. Nosheny, D. Tosun-Turgut, MW Winer, HJ Rosen, BL Miller and D. Perry
University of Southern California, Los Angeles, California, USA
P. Aisen, AW Toga, M. Rafii, R. Raman, G. Jimenez, M. Donohue, D. Gessert, J. Salazar, C. Zimmerman, Y. Cabrera, S. Walter, G. Miller, G. Coker , T. Clanton, L. Hergesheimer, S. Smith, O. Adegoke, P. Mahboubi, S. Moore, J. Pizzola, E. Shaffer, B. Sloan, K. Crawford, S. Neu, LS Schneider, S. Pawluczyk, M. Becerra, L. Teodoro, K. Dagerman and BM Spann
Mayo Clinic, Rochester, Rochester, MN, USA
R. Petersen, CR Jack Jr, A. Forghanian-Arani, B. Borowski, C. Ward, C. Schwarz, D. Jones, J. Gunter, K. Kantarci, M. Senjem, P. Vemuri, R. Reid, SS Mason, CS Albers, D. Knopman and K. Johnson
University of California, Berkeley, Berkeley, California, USA
W. Jagust & S. Landau
University of Pennsylvania, Philadelphia, PA, USA
JQ Trojanowki, LM Shaw, PA Yushkevich, S. Das, JH Karlawish, DA Wolk, S. Vaishnavi, CM Clark and SE Arnold
University of California, Davis, Davis, California, USA
L. Beckett, D. Harvey, C. DeCarli, A. Knaack, and E. Fletcher
Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
RC Green, RA Sperling, KA Johnson and GA Marshall
Indiana University, Bloomington, IN, USA
AJ Saykin, K. Nho, SL Risacher, LG Apostolova, TM Foroud, K. Nudelman, K. Faber, K. Wilmes, MR Farlow, AM Hake, BR Matthews, JR Brosch & S. Herring
Washington University in St. Louis, St. Louis, MO, USA
JC Morris, RJ Perrin, R. Perrin, NJ Cairns, E. Householder, E. Franklin, H. Bernhardt, L. Taylor-Reinwald, B. Ances, D. Winkfield, M. Carroll, G. Stobbs-Cucchi, A Oliver, ML Creech, MA Mintun and S. Schneider
Preventing Alzheimer’s Disease, Rockville, MD, USA
Z. Khachaturian
Alzheimer’s Association, Chicago, Illinois, USA
Mr Carrillo
National Institute of Mental Health, Bethesda, MD, USA
W.Potter
Rush University, Chicago, Illinois, USA
L. Barnes, RC Shah, M. Lamar and P. Samuels
National Institute on Aging, Bethesda, MD, USA
M. Bernard, E. Masliah, L. Ryan, N. Silverberg and JK Hsiao
University of California, San Diego, San Diego, California, USA
H. González, L. Thal, J. Brewer, H. Vanderswag and A. Fleisher
Denali Therapeutics, South San Francisco, CA, USA
C. Ho
National Institutes of Health, Bethesda, MD, USA
JK Hsiao
Massachusetts General Hospital, Boston, MA, USA
J.Jackson
Biogen, Cambridge, MA, USA
D. Masterman
University of Wisconsin, Madison, Madison, WI, USA
O. Okonkwo, S. Johnson, S. Asthana and CM Carlson
Eli Lilly, Indianapolis, IN, USA
A.Fleisher
The Veterans Health Research Institute, Northern California Institute for Research and Education, San Francisco, California, USA
DT Sacrey, C. Conti, D. Veitch, M. Ashford, D. Flenniken, A. Kormos, SR Chen and M. Choe
University of Washington, Seattle, WA, USA
T. Monine
University College London, London, UK, USA
NC Fox and I. Malone
University of Southern California School of Medicine, Los Angeles, California, USA
P. Thompson, SI Thomopoulos, TM Nir, N. Jahanshad & K. Crawford
University of Michigan, Ann Arbor, MI, USA
RA Koeppe, J. Ziolkowski, JL Heidebrink, L. Zbizek-Nulph & JL Lord
Alzheimer’s Institute banner, Phoenix, AZ, USA
EM Reiman, K. Chen, A. Perrin and A. Burke
University of Pittsburgh, Pittsburgh, Pennsylvania, USA
C. Mathis, OL Lopez, M. Oakley and DM Simpson
Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
LM Shaw, JQ Tojanowki, M. Korecka, M. Figurski & L. Shen
Oregon Health and Science University, Portland, OR, USA
LC Silbert, B. Lind, R. Crissey, JA Kaye, R. Carter, S. Dolen and J. Quinn
Baylor College of Medicine, Houston, Texas, USA
J. Villanueva-Meyer, V. Pavlik, N. Pacini, A. Lamb, JS Kass, RS Doody, V. Shibley, M. Chowdhury, S. Rountree and M. Dang
Columbia University Medical Center, New York, NY, USA
Y. Stern, LS Honig and A. Mintz
University of Alabama, Birmingham, Birmingham, AL, USA
D. Geldmacher, MN Love, R. Griffith, D. Clark, J. Brockington and D. Marson
Mount Sinai School of Medicine, New York, NY, USA
H. Grossman, MA Goldstein, J. Greenberg and E. Mitsis
Wien Center for Alzheimer’s Disease and Memory Disorders, Miami, Florida, USA
R. Duara, MT Greig-Custo & R. Rodriguez
Johns Hopkins University, Baltimore, MD, USA
M. Albert, C. Onyike, L. Farrington, S. Rudow, R. Brichko and S. Kielb
University of South Florida: Health Byrd Alzheimer’s Institute, Tampa, Florida, USA
A. Smith, BA Raj and K. Fargher
New York University, New York, NY, USA
M. Sadowski, T. Wisniewski, M. Shulman, A. Faustin, J. Rao, KM Castro, A. Ulysse, S. Chen, MO Sheikh & J. Singleton-Garvin
Duke University Medical Center, Durham, North Carolina, USA
PM Doraiswamy, JR Petrella, O. James, TZ Wong and S. Borges-Neto
University of Rochester Medical Center, Rochester, NY, USA
AP Porsteinsson, K. Martin, N. Kowalski, M. Keltz, BS Goldstein, KM Makino, MS Ismail & C. Brand
University of California Irvine Institute for Memory Disorders and Neurological Disorders, Irvine, CA, USA
G. Thai, A. Pierce, B. Yanez, E. Sosa and M. Witbracht
University of Texas Southwestern School of Medicine, Dallas, TX, USA
B. Kelley, T. Nguyen, K. Womack, D. Mathews and M. Quiceno
Emory University, Atlanta, Georgia, USA
AI Levey, JJ Lah, I. Hajjar and JS Cellar
University of Kansas Medical Center, Kansas City, KS, USA
JM Burns, RH Swerdlow and WM Brooks
University of California, Los Angeles, Los Angeles, California, USA
DHS Silverman, S. Kremen, L. Apostolova, K. Tingus, PH Lu, G. Bartzokis, E. Woo and E. Teng
Mayo Clinic, Jacksonville, Jacksonville, Florida, USA
NR Graff-Radford, F. Parfitt and K. Poki-Walker
Yale University School of Medicine, New Haven, CT, USA
CH van Dyck, AP Mecca, SP Good, MG MacAvoy, RE Carson & P. Varma
McGill University, Jewish General Hospital of Montreal, Montreal, Quebec, Canada
H. Chertkow, S. Vaitekunis & C. Hosein
Sunnybrook Health Sciences, Ontario, Toronto, Ontario, Canada
S. Black, B. Stefanovic and C. Heyn
Alzheimer’s Disease and Related Disorders Clinic, University of British Columbia, Vancouver, British Columbia, Canada
GR Hsiung, E. Kim, B. Mudge, V. Sossi, H. Feldman & M. Assaly
St. Joseph’s Health Care, London, Ontario, Canada
E. Finger, S. Pasternak, I. Rachinsky, A. Kertesz, D. Drost and J. Rogers
Northwestern University, Evanston, Illinois, USA
I. Grant, B. Muse, E. Rogalski, J. Robson, M. Mesulam, D. Kerwin, C. Wu, N. Johnson, K. Lipowski, S. Weintraub & B. Bonakdarpour
Nathan Kline Institute, Orangeburg, NY, USA
N. Pomara, R. Hernando & A. Sarrael
Georgetown University Medical Center, Washington, DC, USA
RS Turner, K. Johnson, B. Reynolds, K. McCann and J. Poe
Stanford University, Stanford, California, USA
J. Yesavage, JL Taylor, S. Chao, J. Coleman, JD White, B. Lane, A. Rosen, and J. Tinklenberg
Banner Sun Health Research Institute, Sun City, Arizona, USA
CM Belden, A. Atri, BM Spann, KA Clark, E. Zamrini and M. Sabbagh
Boston University, Boston, MA, USA
R. Killiany, R. Stern, J. Mez, N. Kowall and A. E. Budson
Howard University, Washington, DC, USA
To Obisesan, OE Ntekim, S. Wolday, JI Khan, E. Nwulia and S. Nadarajah
Case Western Reserve University, Cleveland, Ohio, USA
A. Lerner, P. Ogrocki, C. Tatsuoka and P. Fatica
University of California, Davis-Sacramento, Sacramento, CA, USA
E. Fletcher, P. Maillard, J. Olichney, C. DeCarli & O. Carmichael
Dent Neurologic Institute, Amherst, NY, USA
V. Bates, H. Capote & M. Rainka
Parkwood Institute, London, Ontario, Canada
M. Borrie, T. Lee and R. Bartha
Ohio State University, Columbus, OH, USA
DW Scharre, M. Kataki, R. Tarawneh & B. Kelley
Albany Medical College, Albany, NY, USA
D. Hart, EA Zimmerman and D. Celmins
University of Iowa College of Medicine, Iowa City, IA, USA
DD Miller, LLB Ponto, KE Smith, H. Koleva, H. Shim, KW Nam and SK Schultz
Wake Forest University Health Sciences, Winston-Salem, North Carolina, USA
JD Williamson, S. Craft, J. Cleveland, M. Yang and KM Sink
Rhode Island Hospital, Providence, RI, USA
BR Ott, JD Drake, G. Tremont & LA Daiello
Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA
M. Sabbagh, A. Ritter, C. Bernick, D. Munic and A. Mintz
Roper St. Francis Healthcare, Charleston, South Carolina, USA
A. O’Connell, J. Mintzer and A. Williams
Houston Methodist Neurological Institute, Houston, Texas, USA
J.Masdeu
Barrow Neurological Institute, Phoenix, Arizona, USA
J. Shi, A. Garcia and M. Sabbagh
Vanderbilt University Medical Center, Nashville, TN, USA
P.Newhouse
Long Beach Veterans Affairs Neuropsychiatric Research Program, Long Beach, California, USA
S.Potkin
Butler Hospital Memory and Aging Program, Warren Alpert Medical School, Brown University, Providence, RI, USA
S. Salloway, P. Malloy & S. Correia
New York Center Neurological Care, Liverpool, NY, USA
S.Kittur
Hartford Hospital, Olin Neuropsychiatry Research Center, Hartford, CT, USA
GD Perlson, K. Blank and K. Anderson
Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA
LA Flashman, M. Seltzer, ML Hynes and RB Santulli
Cornell University, Ithaca, NY, USA
N. Relkin, G. Chiang, A. Lee, M. Lin and L. Ravdin
All authors contributed to this work and approved the final version of this manuscript. MLP, ELV and MEC should be considered co-first authors. They each contributed intellectually to the development of the PRSKB website and command line interface. They were primarily responsible for writing the manuscript and online documentation, testing the PRSKB and related methods, and organizing the workflows. ER and LD helped develop the online interface, wrote some sections of the manuscript, and tested the PRSKB. MTWE helped edit the manuscript, provided resources for its completion, and contributed intellectually by suggesting some additional features. The Alzheimer’s Disease Neuroimaging Initiative provided genetic data that was used to validate PRSKB. JBM and JSKK should be considered co-last authors. JBM and JSKK were the main intellectual drivers of this tool, directed and mentored the other authors, provided resources to develop and deploy the PRSKB, wrote and edited the manuscript, and ensured the integrity of all analyses.
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